Literature

Articles, posters and presentations

Bence Jones Proteinuria : experimentation of a new immunoturbidimetric method to determine Free Light Chains in non concentrated urines

Biochimica Clinica, 12, 1988, p.: 1451-1457
Abate L., Martelli M., Zannini R.

Original title Proteinuria di Bence Jones: sperimentazione di un nuovo metodo immunoturbidimetrico per la determinazione delle Catene Leggere Libere nelle urine non concentrate
Comments First article wich reports the study of the functionality of the method for determining FLCs by liquid-phase immunoprecipitation as a screening test in the study of Bence Jones proteinuria.
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Immunoturbidimetric-Immunonephelometric Method for the determination of Free Light Chains in Urine

Riunione SIBioC/Proteine – Asti October 17-19th 1989
Massaro L.
New Scientific Company – Cormano (Milano)

Original title Metodo Immunoturbidimetrico-Immunonefelometrico per la Determinazione delle Catene Leggere Libere nelle Urine
Comments Exhibition of the presentation of the method at the congress on proteins held by the SIBioC (Italian Society of Clinical Biochemistry) in 1989.
Download PDF available in NSC (ref. BM-02)

Use of the test-tube precipitation test for urinary immunoglobulins or their fragments present in monoclonal gammopathies

Biochimica Clinica, 13, 1989, p.: 1237-1240
Migliorati T.

Original title Uso della prova di Precipitazione in Provetta per Immunoglobuline Urinarie o loro frammenti presenti in Gammopatie Monoclonali
Comments Another article which studies the functionality of the method for determining FLCs as screening in the study of Bence Jones proteinuria.
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Letter to F. Aguzzi

L’Angolo dell’Elettroforesi – Biochimica Clinica, 14, 1990, p.: 70-72
Massaro L.
New Scientific Company – Cormano (Milano)

Original title Lettera a F. Aguzzi
Comments Letter from L. Massaro to F. Aguzzi, coordinator of the protein section in the magazine of the SIBioC, in reply to his comments on the aforementioned article by Abate L., Martelli M. and Zannini R.
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AL Amyloidosis or AH Amyloidosis ?

Biochimica Clinica, 14, 1990, p.: 471-472
Alecci A., Brandini A.

Original title Amiloidosi AL o Amiloidosi AH ?
Comments La ricerca delle CLL con ImmunoPrecipitazione in fase liquida con i kit New Scientific Company (NSC) viene eseguita nel siero per caratterizzare il tipo di Amiloidosi.
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Proposal of a working model for research into Bence Jones Proteinuria

Poster – Proteins ecc – Padova, May 16-17th 1991
Martelli M., Zannini R.

Original title
Comments Poster presented at the 1991 congress of the SIBioC, showing the results obtained with the use of the method for determining the FLCs, automated in an APS nephelometer, as screening in the study of BJPs.
Download PDF available in NSC (ref. BM-06)

Qualitative and Quantitative Research of Bence Jones Proteins

Gior. It. Chim. Clin., 16, 6, 1991, p.: 403-407
Valenti D., Lenzi MC., Mammmini P.

Original title Ricerca qualitativa e quantitativa delle Proteine di Bence Jones
Comments Another article in wich the application of the method for determining FLCs in the study of the BJPs is discussed.
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“Pseudo-oligoclonal” Free Light Chains in urine: Reflections resulting from recent works – Letter to F. Aguzzi

L’Angolo dell’Elettroforesi – Biochimica Clinica, 16, 1992, p.: 1213-1215
Massaro L.
New Scientific Company – Cormano (Milano)

Original title Catene Leggere Libere “pseudo-oligoclonali” in urine: Riflessioni indotte da recenti lavori – Lettera a F. Aguzzi
Comments Letter from L. Massaro to F. Aguzzi, coordinator of the protein section in the magazine of the SIBioC, which sets forth theoretical reflections on a subject of wide discussion at the time, the origin or cause of the electrophoretic pattern known as ladders.
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Utility of dosing Kappa and Lambda Light Chains via Nephelometry

Poster – XII Congresso SEQC – Murcia, October 29-31st 1993
Alsina M., Soler M., Vidal J., Pérez E.
Laboratori Immunología – Hospital Mutua de Terrassa – Terrassa (Barcelona)

Original title Utilidad de la dosificación de las Cadenas Ligeras Kappa y Lambda por Nefelometría
Comments Poster presented at the 1993 SEQC congress (Spanish Society of Clinical Chemistry) reporting the results obtained using the method to determine FLCs as Screening in the study of BJPs.
Download PDF available in NSC (ref. BM-09)

Assessment of Free Light Chain nephelometric quantification as Screening for Bence Jones Proteinuria

Poster XIII Congresso SEQC – Salamanca,  October 13-15th 1994
Martinez-Bru C., Planella T., Cortés M., González-Sastre F.
Laboratori Bioquímica – Hospital de la Santa Creu i Sant Pau – Barcelona

Original title Evaluación de la cuantificación nefelométrica de Cadenas Ligeras Libres como Screening de Proteinuria de Bence Jones
Comments Another Poster, presented at the 1994 SEQC congress, reporting the results obtained using the method to determine FLCs as Screening in the study of BJPs.
Download PDF available in NSC (ref. BM-10)

Multicentric Evaluation of Methods and Protocols for Free Light Chains and Bence Jones Proteins in urine – First Results

Biochimica Clinica, 19, 1995, p.: 410-425
Milanesi MG. et altri
Commissione InterRegionale “Forlì” su “Proteine di Bence Jones e Catene Leggere Libere”

Original title Valutazione Multicentrica di Metodi e Protocolli per le Catene Leggere Libere e Proteine di Bence Jones in urine – Primi Risultati
Comments This article reports the results obtained by the “Forli” Study Group in their first multicentric studies on methods and protocols usually used to study Bence Jones proteinuria.
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A new ImmunoNephelometric method for Free Light Chains assay in the Cerebrospinal Fluid of neurological patients: preliminary results

European Charcot Foundation. Symposium “Body fluid markers for course and activity of disease in Multiple Sclerosis”. Madrid, October 2-4th 1997
Procaccianti G., Cucci A., Scaringi R. Massaro L.

Original title
Comments Communication presented at the 1997 European Charcot Foundation congress, reporting the results obtained using the method to determine FLCs in cerebrospinal fluid in different neurological affections, particularly in Multiple Sclerosis.
Download PDF available in NSC (ref. BM-12)

 Catene Leggere Libere e Proteine di Bence Jones – Revision

I Edition: I Riunione su “Catene Leggere Libere e Proteine di Bence Jones”, Forlì, May 28th 1993
II Edition: XIV Corso di Biochimica Clinica, Barcellona, November  23-26th  1994
III Edition: V Riunione su “Catene Leggere Libere e Proteine di Bence Jones”, Forlì, May 26th 1995
IV Edition: Incontro “Proteine Urinarie – Clinica e Diagnostica”, Pesaro, June 23rd 1999
V Edition: Corso CEFAR “Le Proteine: dal Laboratorio alla Clinica”, Desenzano, October 13-15th 1999
V Edition, October 1999

Massaro L., Scaringi R.
New Scientific Company – Cormano (Milano)

Original title Catene Leggere Libere e Proteine di Bence Jones – Review
Comments Complete revision of the argument on the determination of Free Light Chains and Bence Jones proteins, with special emphasis on their physiopathology, theoretical aspects and problems of their determination and revision of available methods.
It includes a large bibliographical list.
Download PDF IT ES

Multicentric Evaluation of Routine Commercial Methods to detect Bence Jones Proteins in urine

Meeting SIBioC – CEFAR “Le Proteine: dal Laboratorio alla Clinica” – VIII edizone – Desenzano, 1999
Gruppi di studio “Forlì” e “Liguria” su “Proteine di Bence Jones e Catene Leggere Libere”
presentato da: Tizzanini W. (Laboratorio Analisi – Azienda Policlinico – Modena)

Original title Valutazione Multicentrica di Metodi commerciali di routine per la ricerca delle Proteine di Bence Jones nelle urine
Comments Presentation of the results obtained by the Study Groups “Forlì” and “Liguria”, in their studies on methods normally used in the study of BJP, at the joint Meeting of SIBioC and the CEFAR Course on proteins.
Further information, on results obtained by the Study Groups in their experiments, can be found on the page referring to BJP Study Groups.
Download PDF IT EN ES

Multicentric Evaluation of routine commercial methods to detect Bence Jones Proteins in urine

Meeting SIBioC – CEFAR – “Le Proteine: dal Laboratorio alla Clinica” – IX edizione – Fiuggi, 2000
Gruppi di studio “Forlì” e “Liguria” su “Proteine di Bence Jones e Catene Leggere Libere”
presentato da: Tizzanini W. (Laboratorio Analisi – Azienda Policlinico – Modena)

Original title Valutazione Multicentrica di Metodi commerciali di routine per la ricerca delle Proteine di Bence Jones nelle urine
Comments Presentation of the results obtained by the Study Groups “Forlì” and “Liguria”, in their studies on methods normally used in the study of BJP, at the joint Meeting of SIBioC and the CEFAR Course on proteins.
Further information, on results obtained by the Study Groups in their experiments, can be found on the page referring to BJP Study Groups.
Download PDF IT ES

Evaluation and Presentation of laboratory Results in Patients suspected of a monoclonal Gammopathy: The value of free light Chains in Bence Jones Testing (Abstract)

Meeting SIBioC – CEFAR – “Proteins: from the Laboratory to the Clinic” – X edizione– Castrocaro, 2001
Regeniter A.(a), Siede WH.(b)
(a) Presenting Author: Central Laboratory – Kantonsspital Basel
(b) Author for correspondence: Central Laboratory – Klinikum Lippe-Lembgo – Lembgo. E-mail: Werner.Siede@klinikum-lippe.de

Original title
Comments Reports the study of the Free Kappa/Free Lambda index functionality as a screening method in the study of Bence Jones proteinuria, proposing for patients suspected of monoclonal gammapathy, the presentation of laboratory results in a single computerized report including preliminary visit data.
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Immunonephelometric Determination of the Free Light Chains of Immunoglobulins in Urine to Detect the Bence Jones Proteins and Comparison with Immunofixation

Meeting SIBioC – CEFAR – “Proteins: from the Laboratory to the Clinic” – X edition – Castrocaro, 2001
Quinzanini M.
Servizio di Reumatologia Immunologia ed Allergologia – Azienda Ospedaliera “Spedali Civili” – Brescia

Original title Determinazione ImmunoNefelometrica delle catene leggere libere delle Immunoglobuline nelle urine per la ricerca delle Proteine di Bence Jones e confronto con l’Immunofissazione
Comments Reports the study of nephelometric FLC determination functionality as a Screening method in the study of Bence Jones proteinuria, making an exhaustive comparison with Immunofixation taken as a reference method.
It includes a complete study of the nephelometric method performances and characteristics for FLC determination.
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Multicentric Evaluation of Routine Commercial Methods to Detect Bence Jones Proteins in Urine – Results 2001

Meeting SIBioC – CEFAR – “Proteins: from the Laboratory to the Clinic” – X edizione – Castrocaro, 2001
Gruppi di studio su “Catene Leggere Libere e Proteine di Bence Jones”: Forlì, Liguria, Lazio, Toscana-Umbría presentato da: Tizzanini W. (Laboratorio Analisi – Azienda Policlinico – Modena)

Original title Valutazione Multicentrica di Metodi commerciali di routine per la ricerca delle Proteine di Bence Jones in urine – Risultati 2001
Comments Joint presentation of results obtained by the different Italian Study Groups in their studies on the methods usually used in the study of BJP.
Further information, on the results obtained by the Study Groups in their experiments, can be found on the page referring to the BJP Study Groups.
Download PDF IT EN ES

Detection of Bence Jones Proteins – A Contribution of the Genoese Galliera Hospital Archives

Meeting SIBioC – CEFAR – “Proteins: from the Laboratory to the Clinic” – X edizione – Castrocaro, 2001
Burlando L.
Già Laboratorio Analisi – Ospedale Galliera – Genova

Original title Ricerca delle Proteine di Bence Jones – Un contributo dall’archivio degli Ospedali Galliera di Genova
Comments Via a retrospective study of the hospital archives, the convenience/need to use anti Free Light Chains antisera in urinary Immunofixation is revised and discussed.
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Monoclonal and Polyclonal Immunoglobulin Free Light Chains (FLC) detection in urine

Meeting SIBioC – CEFAR – “Proteins: from the Laboratory to the Clinic” – X edizione– Castrocaro, 2001
Viedma JA.
Hospital General y Universitario – Elche (Alicante)

Original title
Comments Study of the capacity of different methods to detect monoclonal and polyclonal FLCs in urine.
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Proteinuria – Diagnostics and Interpretation with Marker Proteins: Computerising Processing and report (“MDI–LabLink”)

Meeting SIBioC – CEFAR – “Proteins: from the Laboratory to the Clinic” – X edizione – Castrocaro, 2001
Siede WH.(a), Regeniter A.(b)
(a) Presenting Author: Central Laboratory – Klinikum Lippe-Lembgo – Lembgo
(b) Author for correspondence: Central Laboratory – Kantonsspital Basel
E-mail: aregeniter@uhbs.ch

Original title
Comments Explanation and revision of the concept on the use of specific protein markers in the study of proteinuria and presentation of the Software “MDI-LabLink” enabling its computerization.
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Usefulness of Determining Free Light Chains in Urine via Nephelometry for the Study of Bence Jones Proteinuria

Poster – XXI Congresso SEQC – Gijón, 9-11 Ottobre 2002
Iglesias N., García-Vitoria M., Hernández M., Galimany R., Rodrigo MJ.
Laboratoris Clinics – Hospital Vall d’Hebrón – Barcelona

Original title Utilidad de la Determinación de Cadenas Ligeras Libres en Orina por Nefelometría para el Estudio de la Proteinuria de Bence Jones
Comments Study of the effectiveness of using the FLC nephelometric measurement as Screening method to detect Bence Jones proteinuria.
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Evaluation of an ImmunoFixation Electrophoresis selective method for Bence Jones Proteinuria Identification

15th European Congress of Clinical Chemistry and Laboratory Medicine
22nd National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC)
EUROMEDLAB – Barcelona 2003
Quiñones-Torrelo C., Del Valle-Pérez R., González-Ovelar M., Jarabo-Bueno MM., Díaz-Ruiz M.,
Montagud-Palau A., González-Monleón L., Marco-López P.
Sección de Inmunoquímica – Departamento de Análisis Clínicos – Hospital Universitari “Dr. Peset” – Valencia

Original title
Comments Study of the Immunofixation method sensitivity used in the study of BJP in various groups of patients classified according their FLC concentration nephelometrically measured.
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ImmunoNephelometric Determination of Free Light Chains in Urine as Screening for the Detection of Bence Jones Proteinuria

15th European Congress of Clinical Chemistry and Laboratory Medicine
22nd National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC)
EUROMEDLAB – Barcelona 2003
García-Vitoria M., Cortina A., Iglesias N., Hernández M., García-Guantes, E., Besalú C., Galimany R., Rodrigo MJ.
Laboratoris Clinics – Hospital Vall d’Hebrón – Barcelona

Original title
Comments Study of the effectiveness of using the nephelometric measurement of FLC as a Screening method to detect the Bence Jones proteinuria.
Download PDF EN

ImmunoNephelometric Determination of Free Light Chains of Immunoglobulins in Urine for the Detection of Bence Jones Proteins, and Comparison with Immunofixation

15th European Congress of Clinical Chemistry and Laboratory Medicine
22nd National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology (SEQC)
EUROMEDLAB – Barcelona 2003
Quinzanini M.
Servizio di Reumatologia Immunologia ed Allergologia – Azienda Ospedaliera “Spedali Civili” – Brescia

Original title
Comments Reports the study on the functionality of the FLC nephelometric determination as a Screening method in the study of Bence Jones proteinuria making an exhaustive comparison with the Immunofixation taken as the reference method.
To highlight the focus novelty, centered on improving the quality of the process and final result obtained (in the study of Bence Jones proteinuria) provided by the use of nephelometry as a Screening method
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Immunonephelometric Determination of Immunoglobulin Free Light Chains in Urine

Analisis Clinicos 2003;28(1):7-14
Jiménez, M.; Preciado, E.; Mateo, G.; Rodríguez, M. M.; García-Valdecasas, I.
Laboratorio de Bioquímica – Hospital Txagorritxu – Vitoria

Original title Determinación Inmunonefelométrica de Cadenas Ligeras Libres de Inmunoglobulinas en Orina
Comments Assessment of the Free Light Chain measurement nephelometric method performances and evaluation of its use as screening method in the study of the Bence Jones proteinuria.
Download PDF ES Document

Other documents

Reviews

Free Light Chains and Bence Jones Proteins
Revision – V Edition, October 1999

Massaro L., Scaringi R.

New Scientific Company – Cormano (Milano)

Original title Catene Leggere Libere e Proteine di Bence Jones Review – V Edizione, Ottobre 1999
Comments Complete revision of the argument on the determination of Free Light Chains and Bence Jones proteins, with special emphasis on their physiopathology, theoretical aspects and problems of their determination and revision of available methods.
It includes a large bibliographical list.
Download PDF IT ES

Presentations

Free Light Chain Kits – Presentation

Massaro L., Scaringi R.
New Scientific Company – Cormano (Milano)

Original title Kit Catene Leggere Libere – Presentazione
Comments Presentation of the NSC’s Free Light Chain kits.
Download PDF IT EN ES PT

Proposals

Operative Protocol for the BJP Study Proposal

S. Portas
New Scientific Company España – Barcelona

Original title Propuesta de Protocolo Operativo para el estudio de las BJP
Comments Proposal of operative protocol based on the use of liquid-phase immunoprecipitation (nephelometry or turbidimetry) as a first-level test, indicative of the presence of free light chains (FLCs), followed up by immunofixation as a confirmation test, to determine whether or not the FLCs present are monoclonal, i.e. Bence Jones (BJP).
Download PDF EN ES PT

Immunofixation (IFE) of urine for Bence Jones Proteins detection
Mini Atlas of Schematic Pattern

Massaro L.
New Scientific Company – Cormano (Milano)

Original title
Comments Revision of the typical urinary immunofixation patterns found in the BJP study.
Download PDF EN